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Technical Papers

Please click on the link or contact Brightwell to request copies of these technical materials.

  • Overlooking Subvisible Particles in Therapeutic Protein Products: Gaps That May Compromise Product Quality, John F. Carpenter, Theodore W. Randolph, Wim Jiskoot, Daan J.A. Crommelin,C. Russell Middaugh, Gerhard Winter, Ying-Xin Fan, Susan Kirshner, Daniela Verthelyi, Steven Kozlowski, Kathleen A. Clouse, Patrick G. Swann, Amy Rosenberg, Barry Cherney. (2008). Journal of Pharmaceutical Science (Commentary, In Press). Follow this link to access the article through Wiley Interscience - Article.

  • Quantitation of protein particles in parenteral solutions using Micro-Flow Imaging, Chi-Ting Huang, Deepak Sharma , Peter Oma , Rajesh Krishnamurthy (2008). Journal of Pharmaceutical Science. Follow this link to access the article through Wiley Interscience - Article.

  • Effect of Pump-Induced Particle Agglomeration on CMP Slurry, Lan Y., Li Y., Solid State Technology, Volume 51, Issue 8, August 2008. Follow this link to the Article.

  • Challenges in Understanding Particle Formation in Primary Containers for Monoclonal Antibody Formulations, Rajan R., AAPS National Biotechnology Conference, www.aapspharmaceutica.com/national, June 22-25, 2008

  • Aggregation in Biopharmaceutical Formulations and Analytical Methods Used, Das T.K., AAPS National Biotechnology Conference, www.aapspharmaceutica.com/national, June 22-25, 2008

  • Analytical Challenges for High Concentration Antibody Formulations, Liu J., AAPS National Biotechnology Conference, www.aapspharmaceutica.com/national, June 22-25, 2008

  • Automatic Flow Microscopy for Pharmaceutical and Biological Analysis, Moore, P., Laboratory Focus, www.bioscienceworld.ca, May 2008, pp. 12-14

  • Emerging Analytical Technologies for Biotherapeutics Development, Krishnamurthy, R., Sukamar, M., Das, T.K., Lacher, N.A., BioProcess International, May 2008, pp 32-42, www.bioprocessintl.com

  • Pre-Treatment of Wastewater Sludge - Biodegradability and Rheology Study, Verma, M., Brar, S.M., Riopel, A.R.,Tyagi, R.D., Surampalli, R.Y., Environmental Technology, Vol. 28, pp 273-284, 2008. www.environtechnol.co.uk

  • Quantitation of Protein Particles in Parenterals Using Light Obscuration and Micro-Flow Imaging, Huang, C. (Immunogen Inc.), 2007, Particle Characterization and Processing Seminar

  • Classification of Particulates within Parenteral Formulations Using Micro-Flow Imaging, Thomas, D., 2007, Particle Characterization and Processing Seminar

  • Light Obscuration Particulate Analysis for Protein Solutions: Challenges and Limitations, Ives C.M. (Amgen Inc.), Soderquist R., Stoner M., Kendrick B.S., 2007 Colorado Protein Stability Conference

  • Quantitation of Protein Particles in Parenteral Solutions Using Light Obscuration and Micro-Flow Imaging, Huang, C. (Immunogen Inc.), Sharma D., Amphlett G., Oma P., Krishnamurthy R., 2007 Colorado Protein Stability Conference

  • Impact of Flocculated Particles on Low Pressure UV Inactivation of E. Coli in Drinking Water, Liu, G., R.M. Slawson, P.M. Huck, 2007, Journal of Water Supply: Research and Technology: Aqua, 56(3): 153-162.

  • Flow Microscopy for Parenteral Formulations, Moore, P., Thomas, D., Pharmaceutical Sciences World Congress (PSWC) 2007, www.fip.org/pswc 

  • Characterization of Parenteral Particle Populations by Flow Microscopy, Thomas, D., Sharma, D., Oma, P., Parenteral Drug Association (PDA) 2007 Annual Meeting, www.pda.org

  • Characterization of Parenteral Particle Populations by Flow Microscopy, Thomas, D., Sharma, D., Oma, P., King, D., ICBPST, 2006

  • Micro-Flow Imaging™; A New Technology for Measuring the Size, Concentration, and Morphology of CMP Slurry Outliers, Burkhard, C., Thomas, D., Symposium on Chemical-Mechanical Planarization, August 2006, http://www.clarkson.edu/camp 

  • Flow Microscopy for Cell Populations, Oma, P., King, D., International Society for Analytical Cytology (ISAC), XXIII International Congress, May 2006, www.isac-net.org 

  • Particle Population Classification By Micro-Flow Imaging™; Thomas, D., Particles 2006 (Medical/Biochemical Diagnostic, Pharmaceutical, and Drug Delivery Applications of Particle Technology), www.nanoparticles.org

  • Minimizing Operational Interruption During Filter Bed Surveillance.  S. Booth, P. Carlson, S. Kawamura.  AWWA Research Foundation and AWWA, 2006.

  • A Closer Look at Filter Effluent Particles Using Image-Based Particle Analysis.  E. Phillipi, G. Harrington, B. Lau, S. Russell, D. Thomas.  Water Quality Technology Conference, Nov 2005.

  • Impacts des particules sur L'efficacite de la desinfection aux UV. M. Prevost, B. Barbeau, G. Chevrefils, E. Caron, P.Payment. Atelier sue l'Eau Potable, Sherbrooke, PQ, October 2005
  • Application of Automatic Micro-Flow Imaging™ to Pathogen Detection and Ennumeration.  D. Thomas, J. Clancy, R. McCuin, T. Matias.  Ontario Water Works Association Conference, May 2005.

  • Use of Microscopic Fluid Imaging for Identification and Quantification of Organisms in Water.  J. Clancy, R. McCuin.  Water Quality Technology Conference, Nov 2005.

  • Dynamic Particle Analysis: A New Technology For Optimizing Particle Removal In A Water Treatment Plant.  I. Douglas, D. Thomas, J. Guthmann, S. Russell, S. Springthorpe.  Water Quality Technology Conference, Nov. 2004.

  • Water Treatment Plant Particle Characterization Using Digital Imaging Technology.  P. Moore, D. Thomas.  Canadian Water Works Association Annual Conference, Apr 2004.

  • Particle Characterization Using Dynamic Digital Image Analysis.  P. Moore, D. Thomas.  Water Quality Technology Conference, Nov 2003.

  • Dynamic Digital Image Analysis: Emerging Technology for Particle Characterization.  G. Rabinski, D. Thomas.  International Water Association, Sept. 2003.

  • Beyond Turbidity – A Quantifiable Analysis of Solids in Drinking Water.  G. Rabinski, D. King.  ICWH, Sept 2002.